Depression and the Seratonin Hypothesis

MindFreedom International News – 8 Nov. 2005


Ads for SSRI antidepressants are misleading, say researchers

Consumer ads for a class of antidepressants called SSRIs often claim that depression is due to a chemical imbalance in the brain, and that SSRIs correct this imbalance, but these claims are not supported by scientific evidence, say researchers in PLoS Medicine.

Although scientists in the 1960s suggested that depression may be linked to low brain levels of the chemical serotonin (the so-called “serotonin hypothesis”), contemporary research has failed to confirm the hypothesis, they say.

The researchers — Jeffrey Lacasse, a doctoral candidate at Florida State University and Dr. Jonathan Leo, a
neuroanatomy professor at Lake Erie College of Osteopathic Medicine — studied US consumer advertisements for SSRIs from print, television, and the Internet. They found widespread claims that SSRIs restore the serotonin balance of the brain. “Yet there is no such thing as a scientifically established correct ‘balance’ of serotonin,” the authors say.

According to Lacasse and Leo, in the scientific literature it is openly admitted that the serotonin hypothesis remains unconfirmed and that there is “a growing body of medical literature casting doubt on the serotonin hypothesis,” which is not reflected in the consumer ads.

For instance, the widely televised animated Zoloft (setraline) commercials have dramatized a serotonin imbalance and stated, “Prescription Zoloft works to correct this imbalance.” Advertisements for other SSRIs, such as Prozac (fluoxetine), Paxil (paroxetine), and Lexapro (escitalopram), have made similar claims.

In the US, the FDA is responsible for regulating consumer advertisements, and requires that they be based on scientific evidence. Yet, according to Lacasse and Leo, the mismatch between the scientific literature and the SSRI advertisements is “remarkable, and possibly unparalleled.”

And while the Irish equivalent of the FDA, the Irish Medicines Board, recently banned GlaxoSmithKline from claiming in their patient information leaflets that paroxetine (Paxil) corrects a chemical imbalance, the FDA has never taken any similar action on this issue.

Commenting on Lacasse and Leo’s work, Professor David Healy of the North Wales Department of Psychological Medicine, said: “The serotonin theory of depression is comparable to the masturbatory theory of insanity. Both have been depletion theories, both have survived in spite of the evidence, both contain an implicit message as to what people ought to do. In the case of these myths, the key question is whose interests are being served by a widespread promulgation of such views rather than how do we test this theory.”

Dr Joanna Moncrieff, Senior Lecturer in Psychiatry at University College London, said: “It is high time that it was stated clearly that the serotonin imbalance theory of depression is not supported by the scientific evidence or by expert opinion. Through misleading publicity the pharmaceutical industry has helped to ensure that most of the general public is unaware of this.”


News Release Contact: Paul Ocampo
415-624-1224 – Public Library of Science


Citation: Lacasse JR, Leo J (2005)
Serotonin and depression: A
disconnect between the advertisements
and the scientific literature. PLoS
Med 2(12): e392.

CONTACTS: Jeffrey Lacasse
(850) 294-0875

Jonathan Leo
941-321-9034 or 941-723-8710


All works published in PLoS Medicine
are open access and may be freely
re-distributed under the Creative
Commons Attribution License.

– end forwarded news release –



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ACTION: Please help inform the public!!

Forward this important news far and wide.

psychiatric drug industry false advertising
about a “chemical imbalance”?

See MindFreedom’s debate with Pfizer, Inc.,
manufacturer of Zoloft:

Also see the historic debate with the
American Psychiatric Association resulting
from MindFreedom’s 2003 hunger strike:

Researcher Jonathan Leo was on the MindFreedom
International Scientific Panel for the hunger strike.